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Astrocytes also produce hyaluronan during chronic demyelination, impairing remyelination by arresting OL differentiation via Toll-like receptor 2 ligation 162,163,164

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Regarding eGFR trajectories, both drugs induced a slightly slower decline in eGFR compared to the placebo groups, which was more pronounced in people with moderate (eGFR 3059 mL/min/1.73 m 2 ) or severe (eGFR 50%, reaching ESKD, death from kidney disease or death from CVD